She played many parts in performances at school and also appeared on Tv during children television shows in Imo state.
She also provided voice acting in the video game Dark Souls II, playing Shanalotte, otherwise known as "the Emerald Herald".
In 2016, she began a starring role as Tulip O'Hare in AMC's Preacher.
On television Negga has appeared in Doctors, Criminal Justice and the Irish series Love Is the Drug.
Her theatre work includes roles in Duck, Titus Andronicus and Lay Me Down Softly. The film is based on the true story of the Lovings, a married interracial couple in the 1950s and 1960s Virginia, whose relationship led to the Supreme Court decision Loving v.
As of 2007, she began working with the Irish theatrical group Pan Pan Theatre.