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Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education (Sichuan University).This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). How to cite this article: Zhang C, Ling Cl, Pang L, Wang Q, Liu Jx, Wang Bs, Liang Jm, Guo Yz, Qin J, Wang Jx. Available from of macromolecular drugs to the brain is impeded by the blood brain barrier.Macromolecular drugs, including peptides and proteins, have been shown to be one of the promising treatments of neurological illness [1].However, the inherent instability in plasma and the weak penetration through the blood brain barrier (BBB) of macromolecular drugs have hindered their further success [2].For 23 possible additional NF-k B targets from microarrays see Takase et al, 2008 See also target gene information and binding sites. Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, PR China;2.

For 9 additional potential NF-k B immune function target genes, see Liu et al., 2003.

Significant binding efficiency to neutrophils, efficient protection of catalase enzymatic activity from degradation and effective transport to receiver cells were revealed in the delivery system.

Delivery of catalase to ischemic subregions and cerebral neurocytes in MCAO mice was significantly enhanced, which obviously reducing infarct volume in MCAO mice.

It has been reported employing neutrophils as vehicle to deliver NPs into inflammatory site. revealed that albumin NPs can be internalized and then delivered across blood barrier into inflammatory lungs and tumors by activated neutrophils [21,].

They also demonstrated that the tumor accumulation of albumin NPs could be mediated by neutrophils when co-injected with TA99 antibody [22].


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